ICG loaded antioxidant functionalized protein nanoparticles for targeted detection of cancer cells in sentinal lymph node.
Cancers of the oral cavity, oropharynx, supraglottis and hypopharynx are associated with a significant risk of metastatic cancer in the draining regional lymph nodes which is undetectable by standard clinical and radiological investigations. The current methodologies involve the injection of a radioactive substance, a blue dye, or both, near the tumor. it has however brought up two limitations- a) a suboptimal sensitivity with occasional false negative results; b) and toxicity and wastage problems associated with radioactive materials and the convetionally used blue dyes which may cause allergic reactions and…